RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
mir-27a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qPCR; dual-luciferase reporter assay
Target
SFRP1
Pathway
WNT SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-27a targets Sfrp1 to induce renal fibrosis in diabetic nephropathy by activating Wnt/beta-Catenin signalling
Year
2020
Function
miR-27a down-regulated sfrp1 and activated wnt/beta-catenin signalling to promote renal fibrosis.